Autoantibody Profile I checks for a group of antibodies the immune system can produce against your own tissues, covering thyroid, liver, stomach and general cell-nucleus markers. It suits people with symptoms such as unexplained fatigue, joint pain, digestive symptoms or a family history of autoimmune conditions who want this investigated. The profile costs £197.50 plus a £50 blood-draw fee, with results in 2 days. Walk in or book online at 117a Harley Street, seven days a week.
A doctor may request this profile for someone with unexplained fatigue, joint or muscle pain, skin changes or digestive symptoms, where an autoimmune cause is one of several possibilities being considered.
It is also used to investigate abnormal liver function results, unexplained anaemia, or symptoms suggestive of thyroid dysfunction, since several of these antibodies relate to those organs.
Some people request it because a close relative has an autoimmune condition, or because they already have one autoimmune diagnosis and their doctor wants to check for others, since these conditions can cluster together.
Fasting is not required for this test and most people do not need any special preparation. If you take medication that affects your immune system, mention this when you book, as your doctor may want this noted alongside your results.
A positive result for one or more of these antibodies can be an early sign of an autoimmune condition affecting the thyroid, liver or stomach, but antibodies can also be present at low levels in people with no disease at all, so a positive result is not a diagnosis by itself.
Because these markers overlap with several different conditions, a doctor needs to interpret them alongside your symptoms, other blood results and sometimes imaging or specialist assessment.
If any of these results are positive, or you have ongoing symptoms such as ongoing fatigue, joint pain or digestive changes, arrange to see a doctor to discuss what further tests or referral might be appropriate.
If you would like a doctor to request the right tests for your symptoms or talk the report through, book a private GP consultation at Medical Express Clinic.
Written by Mr Stephen Lingam. Reviewed by Dr Mohammad Bakhtiar (GMC 4694470) on 24/09/2026.
It screens for antibodies linked to autoimmune thyroid, liver and stomach conditions, plus a general anti-nuclear antibody marker, in a single blood sample.
No, fasting is not required and you can attend at any time of day.
Results are typically available within 2 days of your blood being taken at 117a Harley Street.
Not necessarily. Some people have low levels of these antibodies without any disease, so a doctor needs to interpret a positive result alongside your symptoms and other tests.
Yes, you can walk in or book online directly at 117a Harley Street, seven days a week, with no GP referral needed.