The Coeliac/Gluten Sensitivity Profile checks for the antibodies associated with coeliac disease, using tissue transglutaminase IgA as the main marker alongside total IgA and, where needed, a reflex deamidated Gliadin IgG test. It suits people with digestive symptoms, unexplained anaemia or bloating who eat gluten regularly and want this investigated. The profile costs £246.25 plus a £50 blood-draw fee, with results in 3 days. Walk in or book online at 117a Harley Street, seven days a week.
A doctor may request this profile for someone with ongoing digestive symptoms such as bloating, diarrhoea or abdominal pain, particularly when these do not have an obvious other cause.
It is also used to investigate unexplained iron-deficiency anaemia, weight loss, fatigue or skin rashes, all of which can occasionally be linked to coeliac disease.
Some people request it because a close relative has coeliac disease, since it runs in families and a doctor may recommend screening even without symptoms.
For this test to be accurate, you need to be eating gluten regularly in the weeks before your sample is taken, since stopping gluten beforehand can affect the result. Please state clearly whether you are fasting or non-fasting when you attend, as this is required for this profile. If you have already reduced or stopped gluten, tell the clinic before your appointment.
A raised tissue transglutaminase IgA result suggests your immune system is reacting in a way that is typical of coeliac disease, but it is not a diagnosis by itself. If your total IgA is low, the laboratory automatically runs a deamidated Gliadin IgG test as a more reliable alternative, and a strongly raised or borderline transglutaminase result triggers a further confirmatory antibody test.
These results need to be read by a doctor alongside your symptoms and gluten intake, and a formal coeliac diagnosis usually also involves a specialist referral and, often, a small bowel biopsy.
If your results are raised or borderline, see a doctor before making any changes to your diet, since starting a gluten-free diet before further testing can make coeliac disease harder to confirm.
If you would like a doctor to request the right tests for your symptoms or talk the report through, book a private GP consultation at Medical Express Clinic.
Written by Mr Stephen Lingam. Reviewed by Dr Mohammad Bakhtiar (GMC 4694470) on 24/09/2026.
It measures tissue transglutaminase IgA, the main antibody linked to coeliac disease, alongside total IgA, with an automatic follow-up deamidated Gliadin IgG test if your IgA is low.
Yes, you should be eating gluten regularly in the weeks before the test, as stopping beforehand can lead to a falsely reassuring result.
Results are typically available within 3 days, though a reflex or confirmatory test triggered by your initial result can add extra time.
Not on its own. A raised antibody result needs a doctor's review and usually a specialist referral, often including a small bowel biopsy, to confirm a diagnosis.