KIR (Killer-like Immunoglobulin-like Receptors) Genotyping

This private genetic blood test determines your uterine natural killer cell KIR (killer-cell immunoglobulin-like receptor) haplotype, reported as AA, AB or BB. The catalogue test price is £504.38 plus a £50 phlebotomy fee, with results in 2-3 weeks.

KIR genotyping is most commonly requested by fertility specialists and reproductive immunologists investigating recurrent implantation failure or recurrent miscarriage alongside HLA-C typing.

Written by Mr Stephen Lingam. Reviewed by Dr Hikmat Naoum (GMC 3047637) on 18/10/2026.

Why is KIR genotyping ordered in IVF and fertility care?

Fertility specialists use KIR genotyping, often paired with HLA-C typing, to assess maternal uterine natural killer cell receptor interactions during embryo implantation.

Do I need to fast or time this test to my menstrual cycle?

No. Because KIR genotyping is a DNA test performed on an EDTA venous blood sample, your result does not change with food, medication or menstrual cycle day.

What does a KIR AA, AB or BB result mean?

KIR AA carries mainly inhibitory receptor genes, whereas AB and BB haplotypes include activating KIR genes. Your fertility consultant interprets the haplotype alongside HLA-C.

Can I book HLA-C typing at the same appointment?

Yes. One £50 phlebotomy fee covers multiple blood tests taken in the same visit at 117a Harley Street.